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Molecular and Cellular Biology|November 21, 2012
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancersBenjamin J Shields, Florian Wiede, Esteban N Gurzov, et al.
Immunity|October 9, 2016
Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune ResponseStephanie Gras, Jesseka Chadderton, Claudia M Del Campo, et al.
Science Advances|June 10, 2026
A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological agingChrysovalantou E Xirouchaki, Esther García-Domínguez, Eamon Coughlan, et al.
Cancer Discovery|November 19, 2021
PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor ImmunityFlorian Wiede, Kun-Hui Lu, Xin Du, et al.
Cell|January 17, 2015
Leptin and insulin act on POMC neurons to promote the browning of white fatGarron T Dodd, Stephanie Decherf, Kim Loh, et al.
Cell|November 21, 2018
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCCMarcus Grohmann, Florian Wiede, Garron T Dodd, et al.
Cell Metabolism|October 18, 2011
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistanceKim Loh, Atsushi Fukushima, Xinmei Zhang, et al.
The EMBO Journal|December 6, 2019
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumoursFlorian Wiede, Kun-Hui Lu, Xin Du, et al.
Science Translational Medicine|October 29, 2025
Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft modelsXin Du, Pei K Goh, Chenkai Ma, et al.
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