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Structure (London, England : 1993)|May 30, 2024
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonistGamma Chi, Dawid Jaślan, Veronika Kudrina, et al.
Elife|November 28, 2018
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cellsEva Plesch, Cheng-Chang Chen, Elisabeth Butz, et al.
Cell Chemical Biology|February 24, 2021
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growthMartin Müller, Susanne Gerndt, Yu-Kai Chao, et al.
The EMBO Journal|August 7, 2026
Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activationQianru Mu, Ryo Saito, Franceska Ozola, et al.
The Journal of Cell Biology|April 25, 2025
Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's diseaseMartina Gregori, Gustavo J S Pereira, Robert Allen, et al.
Proceedings of the National Academy of Sciences of the United States of America|February 6, 2023
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretionLora L Martucci, Jean-Marie Launay, Natsuko Kawakami, et al.
Antiviral Research|June 10, 2019
Regulation of influenza A virus mRNA splicing by CLK1Anita Artarini, Michael Meyer, Yu Jin Shin, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 5, 2026
TPC1-dependent control of endosomal pH and transferrin uptake determines cellular iron statusRebecca Deutsch, Simone Jörs, Yvonne Klingl, et al.
The Journal of Allergy and Clinical Immunology|June 4, 2023
Asthma-protective agents in dust from traditional farm environmentsMauricius Marques Dos Santos, Vadim Pivniouk, Bettina Rankl, et al.
Elife|March 14, 2020
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal functionSusanne Gerndt, Cheng-Chang Chen, Yu-Kai Chao, et al.
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