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Biochemistry|June 6, 2009
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804Li Xing, Huey S Shieh, Shaun R Selness, et al.Molecular Endocrinology (Baltimore, Md.)|December 8, 2009
ERRgamma regulates cardiac, gastric, and renal potassium homeostasisWilliam A Alaynick, James M Way, Stephanie A Wilson, et al.The Journal of Biological Chemistry|December 24, 2002
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acidsCelia P Briscoe, Mohammad Tadayyon, John L Andrews, et al.Bioorganic & Medicinal Chemistry Letters|September 16, 2009
Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinaseShaun R Selness, Rajesh V Devraj, Joseph B Monahan, et al.Bioorganic & Medicinal Chemistry Letters|July 28, 2009
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-oneRobert O Hughes, John K Walker, D Joseph Rogier, et al.Science (New York, N.Y.)|January 6, 2001
Prevention of chemotherapy-induced alopecia in rats by CDK inhibitorsS T Davis, B G Benson, H N Bramson, et al.Bioorganic & Medicinal Chemistry Letters|June 23, 2009
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring systemRobert O Hughes, John K Walker, Jerry W Cubbage, et al.Journal of Medicinal Chemistry|March 4, 2010
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5)Robert O Hughes, D Joseph Rogier, E Jon Jacobsen, et al.Bioorganic & Medicinal Chemistry Letters|June 7, 2011
Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinaseShaun R Selness, Terri L Boehm, John K Walker, et al.Bioorganic & Medicinal Chemistry Letters|June 7, 2011
Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinaseShaun R Selness, Rajesh V Devraj, Balekudru Devadas, et al.Pageof 14