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Journal of Medicinal Chemistry|December 20, 2018
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid LeukemiaXiaofei Liang, Beilei Wang, Cheng Chen, et al.
Leukemia|July 30, 2021
Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2Jing Yang, Ellen L Weisberg, Xiaoxi Liu, et al.
European Journal of Medicinal Chemistry|June 20, 2017
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitorsBeilei Wang, Yuanxin Deng, Yongfei Chen, et al.
Oncotarget|April 14, 2016
Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AMLAoli Wang, Hong Wu, Cheng Chen, et al.
Oncotarget|September 15, 2016
Ibrutinib targets mutant-EGFR kinase with a distinct binding conformationAoli Wang, Xiao-E Yan, Hong Wu, et al.
Cell Chemical Biology|November 14, 2017
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase DegraderHai-Tsang Huang, Dennis Dobrovolsky, Joshiawa Paulk, et al.
Leukemia|January 17, 2022
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2Jing Yang, Ellen L Weisberg, Shuang Qi, et al.
British Journal of Cancer|June 5, 2021
Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM)Moshe Lapidot, Abigail E Case, Ellen L Weisberg, et al.
Oncotarget|September 17, 2015
Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC CellsHong Wu, Aoli Wang, Wei Zhang, et al.
Oncotarget|July 23, 2016
Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignanciesXiaochuan Liu, Aoli Wang, Xiaofei Liang, et al.
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