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Journal of Medicinal Chemistry
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August 16, 2011
Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose
Emmanuel H Demont, Sandra Arpino, Rino A Bit, et al.
Bioorganic & Medicinal Chemistry
|
May 20, 2018
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Laura E Jennings, Matthias Schiedel, David S Hewings, et al.
Journal of Medicinal Chemistry
|
May 10, 1996
Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity
P Chen, P T Cheng, M Alam, et al.
Journal of Medicinal Chemistry
|
January 16, 2016
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives
Susan M Westaway, Alex G S Preston, Michael D Barker, et al.
Journal of Medicinal Chemistry
|
February 12, 2008
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
Wei Meng, Bruce A Ellsworth, Alexandra A Nirschl, et al.
Journal of Medicinal Chemistry
|
August 23, 2002
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities
Kyoung Soon Kim, S David Kimball, Raj N Misra, et al.
Journal of Medicinal Chemistry
|
November 2, 2007
Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)
Jun Li, Stephanie Y Chen, James J Li, et al.
Journal of Medicinal Chemistry
|
January 16, 2016
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives
Susan M Westaway, Alex G S Preston, Michael D Barker, et al.
Journal of Medicinal Chemistry
|
November 15, 2022
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432
Philip G Humphreys, Niall A Anderson, Paul Bamborough, et al.
Journal of Medicinal Chemistry
|
January 7, 2022
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate
Philip G Humphreys, Stephen J Atkinson, Paul Bamborough, et al.
Page
of 28
Search research articles
Search
Showing results (261-270 of 272) with videos related to
Sort By:
Page
of 28
Journal of Medicinal Chemistry
|
August 16, 2011
Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose
Emmanuel H Demont, Sandra Arpino, Rino A Bit, et al.
Bioorganic & Medicinal Chemistry
|
May 20, 2018
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Laura E Jennings, Matthias Schiedel, David S Hewings, et al.
Journal of Medicinal Chemistry
|
May 10, 1996
Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity
P Chen, P T Cheng, M Alam, et al.
Journal of Medicinal Chemistry
|
January 16, 2016
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives
Susan M Westaway, Alex G S Preston, Michael D Barker, et al.
Journal of Medicinal Chemistry
|
February 12, 2008
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
Wei Meng, Bruce A Ellsworth, Alexandra A Nirschl, et al.
Journal of Medicinal Chemistry
|
August 23, 2002
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities
Kyoung Soon Kim, S David Kimball, Raj N Misra, et al.
Journal of Medicinal Chemistry
|
November 2, 2007
Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)
Jun Li, Stephanie Y Chen, James J Li, et al.
Journal of Medicinal Chemistry
|
January 16, 2016
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives
Susan M Westaway, Alex G S Preston, Michael D Barker, et al.
Journal of Medicinal Chemistry
|
November 15, 2022
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432
Philip G Humphreys, Niall A Anderson, Paul Bamborough, et al.
Journal of Medicinal Chemistry
|
January 7, 2022
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate
Philip G Humphreys, Stephen J Atkinson, Paul Bamborough, et al.
Page
of 28