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Progress in Neurobiology|May 25, 2012
Cellular mechanisms of γ-secretase substrate selection, processing and toxicityGael Barthet, Anastasios Georgakopoulos, Nikolaos K Robakis
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology|July 13, 2011
Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding proteinAnastasios Georgakopoulos, Jindong Xu, Chijie Xu, et al.
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology|May 21, 2011
Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substratesGael Barthet, Junichi Shioi, Zhiping Shao, et al.
The Journal of Biological Chemistry|November 15, 2008
p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptideZen Kouchi, Gael Barthet, Geo Serban, et al.
The Journal of Biological Chemistry|September 13, 2013
Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2BZhao Xuan, Gael Barthet, Junichi Shioi, et al.
Neuro-Degenerative Diseases|October 2, 2013
Allelic interference: a mechanism for trans-dominant transmission of loss of function in the neurodegeneration of familial Alzheimer's diseaseNikolaos K Robakis, Anastasios Georgakopoulos
Neurobiology of Aging|May 5, 2016
Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutationsAngeliki M Nikolakopoulou, Anastasios Georgakopoulos, Nikolaos K Robakis
Neurobiology of Aging|April 6, 2012
Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptorsGael Barthet, Julie Dunys, Zhiping Shao, et al.
The Journal of Biological Chemistry|August 8, 2009
Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptorsJindong Xu, Claudia Litterst, Anastasios Georgakopoulos, et al.
Cellular and Molecular Life Sciences : CMLS|February 12, 2018
The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesisNoel A Warren, Georgios Voloudakis, Yonejung Yoon, et al.
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