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Diabetes|July 30, 2002
Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonistsGuoqiang Jiang, Qing Dallas-Yang, Zhihua Li, et al.Diabetes|June 28, 2002
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetesNicolas Musi, Michael F Hirshman, Jonas Nygren, et al.Bioorganic & Medicinal Chemistry Letters|September 3, 2003
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonistsAlan D Adams, Zao Hu, Derek von Langen, et al.Biochemical and Biophysical Research Communications|May 4, 2004
MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activitiesThomas W Doebber, Linda J Kelly, Gaochao Zhou, et al.Bioorganic & Medicinal Chemistry Letters|August 25, 2009
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitorsHong C Shen, Fa-Xiang Ding, Qiaolin Deng, et al.The Journal of Biological Chemistry|January 16, 2002
A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol effluxCarl P Sparrow, Joanne Baffic, My-Hanh Lam, et al.Endocrinology|June 20, 2002
A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a)John G Menke, Karen L Macnaul, Nancy S Hayes, et al.Journal of Medicinal Chemistry|August 19, 2005
Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activityGuo Q Shi, James F Dropinski, Yong Zhang, et al.Bioorganic & Medicinal Chemistry Letters|August 18, 2009
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitorsHong C Shen, Fa-Xiang Ding, Qiaolin Deng, et al.Journal of Medicinal Chemistry|June 25, 2005
Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activityGuo Q Shi, James F Dropinski, Brian M McKeever, et al.Pageof 4