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Journal of Medicinal Chemistry|January 7, 2005
3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivityGary L Grunewald, F Anthony Romero, Kevin R CriscioneJournal of Medicinal Chemistry|March 18, 2005
Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1Gary L Grunewald, F Anthony Romero, Kevin R CriscioneBioorganic & Medicinal Chemistry Letters|July 21, 2004
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic dataQian Wu, Kevin R Criscione, Gary L Grunewald, et al.Bioorganic & Medicinal Chemistry Letters|September 20, 2005
Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinityGary L Grunewald, Jian Lu, Kevin R Criscione, et al.Bioorganic & Medicinal Chemistry|November 28, 2006
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitorsGary L Grunewald, Mitchell R Seim, Rachel C Regier, et al.Journal of Medicinal Chemistry|May 12, 2006
Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorinationGary L Grunewald, Mitchell R Seim, Jian Lu, et al.Journal of Medicinal Chemistry|August 20, 2004
Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptorF Anthony Romero, Steven M Vodonick, Kevin R Criscione, et al.Bioorganic & Medicinal Chemistry|November 21, 2007
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferaseGary L Grunewald, Mitchell R Seim, Seema R Bhat, et al.Organic Letters|October 12, 2002
The NH---FC dipole orientation effect for pendant exocyclic CH(2)FDavid C Lankin, Gary L Grunewald, F Anthony Romero, et al.Bioorganic & Medicinal Chemistry Letters|January 28, 2009
Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinolineQian Wu, Joanne M Caine, Stuart A Thomson, et al.Pageof 3