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Bioorganic & Medicinal Chemistry Letters|May 18, 2010
Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonistsDmitry Zuev, Vivekananda M Vrudhula, Jodi A Michne, et al.Bioorganic & Medicinal Chemistry Letters|February 27, 2010
Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R)Vivekananda M Vrudhula, Bireshwar Dasgupta, Sokhom S Pin, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of MigraineGuanglin Luo, Ling Chen, Charles M Conway, et al.Journal of Medicinal Chemistry|November 17, 2012
Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraineGuanglin Luo, Ling Chen, Charles M Conway, et al.Bioorganic & Medicinal Chemistry Letters|May 1, 2021
Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone leadGuanglin Luo, Xiang-Jun Jiang, Ling Chen, et al.Journal of Medicinal Chemistry|March 23, 2023
Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) InhibitorsRichard A Hartz, Vijay T Ahuja, Prasanna Sivaprakasam, et al.Bioorganic & Medicinal Chemistry Letters|May 2, 2013
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal deliveryPrasad V Chaturvedula, Stephen E Mercer, Sokhom S Pin, et al.Bioorganic & Medicinal Chemistry Letters|June 26, 2012
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1Xiaojun Han, Rita L Civiello, Charles M Conway, et al.Bioorganic & Medicinal Chemistry Letters|November 1, 2003
2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacyGene M Dubowchik, Jodi A Michne, Dmitry Zuev, et al.Journal of Medicinal Chemistry|January 12, 2016
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 InhibitorsGuanglin Luo, Ling Chen, Catherine R Burton, et al.Pageof 5