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Investigational New Drugs|March 20, 2020
A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFRJames M Cleary, Emiliano Calvo, Victor Moreno, et al.
Cancer Research|October 30, 2010
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancersTakaaki Sasaki, Katsuhiro Okuda, Wei Zheng, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|November 1, 2013
Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancerDavid A Proia, Chaohua Zhang, Manuel Sequeira, et al.
Nature Cancer|June 28, 2021
A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient TumorsJia Zhou, Camille Gelot, Constantia Pantelidou, et al.
JCO Precision Oncology|September 16, 2021
Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations)Haider Mahdi, Navid Hafez, Deborah Doroshow, et al.
Cancer Research|June 13, 2012
BCL2 suppresses PARP1 function and nonapoptotic cell deathChaitali Dutta, Tovah Day, Nadja Kopp, et al.
Cancer|June 19, 2013
Phase 2 trial of afatinib, an ErbB family blocker, in solid tumors genetically screened for target activationEunice L Kwak, Geoffrey I Shapiro, Seth M Cohen, et al.
Targeted Oncology|December 2, 2022
Phase I Study Evaluating Glesatinib (MGCD265), An Inhibitor of MET and AXL, in Patients with Non-small Cell Lung Cancer and Other Advanced Solid TumorsChristian Kollmannsberger, Herbert Hurwitz, Lyudmila Bazhenova, et al.
Clinical Pharmacology in Drug Development|January 13, 2021
Pharmacokinetics and Safety of PTC596, a Novel Tubulin-Binding Agent, in Subjects With Advanced Solid TumorsGeoffrey I Shapiro, Edward O'Mara, Oscar L Laskin, et al.
Lung Cancer (Amsterdam, Netherlands)|December 11, 2021
A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancerRuth Plummer, Emma Dean, Hendrik-Tobias Arkenau, et al.
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