Showing results (211-220 of 246) with videos related to
Sort By:
Pageof 25
Chemmedchem|July 31, 2018
On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding ThermodynamicsBarbara Wienen-Schmidt, Tobias Wulsdorf, Hendrik R A Jonker, et al.ACS Medicinal Chemistry Letters|March 18, 2021
The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase FurinThuy Van Lam van, Miriam Ruth Heindl, Christine Schlutt, et al.Molecular Pharmacology|August 25, 2011
High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic propertiesSimone Naruhn, Philipp M Toth, Till Adhikary, et al.Journal of Chemical Information and Modeling|December 23, 2025
Natural Product-like Fragments Unlock Novel Chemotypes for a Kinase Target─Exploring Options beyond the FlatlandAnna Santura, Janis Müller, Madita Wolter, et al.Chemistry (Weinheim an Der Bergstrasse, Germany)|June 28, 2012
From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersLuzi Jakob Barandun, Florian Immekus, Philipp C Kohler, et al.Journal of Medicinal Chemistry|September 2, 2005
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complexTatiana Petrova, Holger Steuber, Isabelle Hazemann, et al.Acta Crystallographica. Section D, Structural Biology|September 2, 2021
Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template dockingAlexander Metz, Jan Wollenhaupt, Steffen Glöckner, et al.Acta Crystallographica. Section F, Structural Biology Communications|May 4, 2016
Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment libraryFranziska U Huschmann, Janina Linnik, Karine Sparta, et al.Chembiochem : a European Journal of Chemical Biology|May 12, 2006
An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitorsSamer I Al-Gharabli, Syed T Ali Shah, Steffen Weik, et al.Journal of Medicinal Chemistry|September 7, 2022
Magnet for the Needle in Haystack: "Crystal Structure First" Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical SpacesJanis Müller, Raphael Klein, Olga Tarkhanova, et al.Pageof 25