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Science Translational Medicine|March 18, 2026
Lowering the <i>HTT1a</i> transcript as an effective therapy for Huntington's disease in a knockin mouse modelAikaterini Smaragdi Papadopoulou, Julia Alterman, Christian Landles, et al.
Plos Biology|December 5, 2013
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegenerationMichal Mielcarek, Christian Landles, Andreas Weiss, et al.
Neuron|February 3, 2022
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC miceXiaofeng Gu, Jeffrey Richman, Peter Langfelder, et al.
The Journal of Experimental Medicine|July 16, 2008
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's diseaseMaria Björkqvist, Edward J Wild, Jenny Thiele, et al.
Glia|September 13, 2016
Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specificAnne H P Jansen, Maurik van Hal, Ilse C Op den Kelder, et al.
Genome Research|April 25, 2015
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicityMartin Stroedicke, Yacine Bounab, Nadine Strempel, et al.
Molecular Cell|September 8, 2018
mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's DiseaseAnne Ast, Alexander Buntru, Franziska Schindler, et al.
Biorxiv : the Preprint Server for Biology|July 16, 2025
Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in miceJillian Belgrad, Ashley Summers, Christian Landles, et al.
Molecular Cell|May 7, 2016
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse ModelVaishali Kakkar, Cecilia Månsson, Eduardo P de Mattos, et al.
Cell Reports|July 23, 2013
SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulationJacqueline Gire O'Rourke, Jaclyn R Gareau, Joseph Ochaba, et al.
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