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Graeme Semple

Showing results (31-40 of 51) with videos related to

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ACS Medicinal Chemistry Letters|December 21, 2017
Discovery of APD371: Identification of a Highly Potent and Selective CB<sub>2</sub> Agonist for the Treatment of Chronic PainSangdon Han, Lars Thoresen, Jae-Kyu Jung, et al.
Bioorganic & Medicinal Chemistry Letters|June 17, 2008
Novel H3 receptor antagonists with improved pharmacokinetic profilesVincent J Santora, Jonathan A Covel, Rena Hayashi, et al.
The Journal of Biological Chemistry|April 25, 2007
Nicotinic acid receptor agonists differentially activate downstream effectorsJeremy G Richman, Martha Kanemitsu-Parks, Ibragim Gaidarov, et al.
Journal of Medicinal Chemistry|August 14, 2008
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119Graeme Semple, Beatriz Fioravanti, Guillherme Pereira, et al.
Journal of Medicinal Chemistry|August 6, 2010
Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomniaYifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, et al.
Bioorganic & Medicinal Chemistry Letters|January 24, 2012
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profileGraeme Semple, Juerg Lehmann, Amy Wong, et al.
Bioorganic & Medicinal Chemistry Letters|March 30, 2011
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose controlGraeme Semple, Albert Ren, Beatriz Fioravanti, et al.
Journal of Medicinal Chemistry|May 12, 2010
Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosisYifeng Xiong, Bradley R Teegarden, Jin-Sun Karoline Choi, et al.
Bioorganic & Medicinal Chemistry Letters|December 17, 2011
Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)Graeme Semple, Vincent J Santora, Jeffrey M Smith, et al.
Bioorganic & Medicinal Chemistry Letters|January 16, 2008
A new family of H3 receptor antagonists based on the natural product ConessineVincent J Santora, Jonathan A Covel, Rena Hayashi, et al.
Pageof 6

Showing results (31-40 of 51) with videos related to

Sort By:
Pageof 6
ACS Medicinal Chemistry Letters|December 21, 2017
Discovery of APD371: Identification of a Highly Potent and Selective CB<sub>2</sub> Agonist for the Treatment of Chronic PainSangdon Han, Lars Thoresen, Jae-Kyu Jung, et al.
Bioorganic & Medicinal Chemistry Letters|June 17, 2008
Novel H3 receptor antagonists with improved pharmacokinetic profilesVincent J Santora, Jonathan A Covel, Rena Hayashi, et al.
The Journal of Biological Chemistry|April 25, 2007
Nicotinic acid receptor agonists differentially activate downstream effectorsJeremy G Richman, Martha Kanemitsu-Parks, Ibragim Gaidarov, et al.
Journal of Medicinal Chemistry|August 14, 2008
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119Graeme Semple, Beatriz Fioravanti, Guillherme Pereira, et al.
Journal of Medicinal Chemistry|August 6, 2010
Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomniaYifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, et al.
Bioorganic & Medicinal Chemistry Letters|January 24, 2012
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profileGraeme Semple, Juerg Lehmann, Amy Wong, et al.
Bioorganic & Medicinal Chemistry Letters|March 30, 2011
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose controlGraeme Semple, Albert Ren, Beatriz Fioravanti, et al.
Journal of Medicinal Chemistry|May 12, 2010
Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosisYifeng Xiong, Bradley R Teegarden, Jin-Sun Karoline Choi, et al.
Bioorganic & Medicinal Chemistry Letters|December 17, 2011
Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)Graeme Semple, Vincent J Santora, Jeffrey M Smith, et al.
Bioorganic & Medicinal Chemistry Letters|January 16, 2008
A new family of H3 receptor antagonists based on the natural product ConessineVincent J Santora, Jonathan A Covel, Rena Hayashi, et al.
Pageof 6