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Molecular Cancer Therapeutics|December 30, 2025
In vivo Auto-tuning of Antibody-Drug Conjugate Delivery to Maximize Efficacy using High-Avidity, Low-Affinity AntibodiesAnna Kopp, Shujun Dong, Hyeyoung Kwon, et al.Nature Communications|November 10, 2020
Co-administered antibody improves penetration of antibody-dye conjugate into human cancers with implications for antibody-drug conjugatesGuolan Lu, Naoki Nishio, Nynke S van den Berg, et al.Neoplasia (New York, N.Y.)|January 1, 2021
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mappingEshita Khera, Cornelius Cilliers, Michael D Smith, et al.Cancer Research|January 17, 2020
Increased Tumor Penetration of Single-Domain Antibody-Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer ModelsIan Nessler, Eshita Khera, Steven Vance, et al.ACS Medicinal Chemistry Letters|August 25, 2017
Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168)Marcian E Van Dort, Stefanie Galbán, Charles A Nino, et al.Molecular Cancer Therapeutics|November 12, 2020
Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase In Vivo EfficacyJose F Ponte, Leanne Lanieri, Eshita Khera, et al.Clinical Pharmacology and Therapeutics|August 15, 2018
Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment PuzzleImke H Bartelink, Ella F Jones, Sheerin K Shahidi-Latham, et al.Nature Biotechnology|June 3, 2026
Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumorsGuolan Lu, John W Hickey, Maximilian Haist, et al.Pageof 7