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Nature Communications|May 15, 2021
Electromechanical coupling mechanism for activation and inactivation of an HCN channelGucan Dai, Teresa K Aman, Frank DiMaio, et al.
Proceedings of the National Academy of Sciences of the United States of America|May 25, 2016
Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levelsGucan Dai, Haijie Yu, Martin Kruse, et al.
Biorxiv : the Preprint Server for Biology|February 20, 2025
Voltage Sensor Conformations Induced by LQTS-associated Mutations in hERG Potassium ChannelsAaron N Chan, Lucas J Handlin, Erin N Lessie, et al.
The Journal of General Physiology|January 13, 2018
Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosisDonald W Hilgemann, Gucan Dai, Anthony Collins, et al.
Biorxiv : the Preprint Server for Biology|July 15, 2025
Cholesterol inhibits HCN channels through dual mechanisms in neuropathic painLucas J Handlin, Clémence Gieré, Nicolas L A Dumaire, et al.
The Journal of General Physiology|March 12, 2026
Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neuronsLucas J Handlin, Clémence Gieré, Nicolas L A Dumaire, et al.
Biorxiv : the Preprint Server for Biology|July 16, 2025
RhoA activation promotes ordered membrane domain coalescence and suppresses neuronal excitabilitySoheila Sabouri, Lucas J Handlin, Natalie L Macchi, et al.
Nature Communications|August 2, 2025
Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channelsAaron N Chan, Co D Quach, Lucas J Handlin, et al.
Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids|February 13, 2017
Fatty-acyl chain profiles of cellular phosphoinositidesAlexis Traynor-Kaplan, Martin Kruse, Eamonn J Dickson, et al.
Nature Communications|November 15, 2024
Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neuronsLucas J Handlin, Natalie L Macchi, Nicolas L A Dumaire, et al.
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