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Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|June 15, 2017
ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor TypesAnderly C Chüeh, Janson W T Tse, Michael Dickinson, et al.Cell Death and Differentiation|February 4, 2023
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cellsZilu Wang, Huimin Hu, Luuk Heitink, et al.Elife|November 3, 2016
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancerStephanie Berger, Erik Procko, Daciana Margineantu, et al.The Biochemical Journal|April 28, 2023
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinaseCatia L Pierotti, Annette V Jacobsen, Christoph Grohmann, et al.Journal of Medicinal Chemistry|March 4, 2011
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activityBrad E Sleebs, Peter E Czabotar, Wayne J Fairbrother, et al.Molecular Cell|November 18, 2017
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based DesignJason M Brouwer, Ping Lan, Angus D Cowan, et al.Cell Reports|November 29, 2018
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β ActivationJames E Vince, Dominic De Nardo, Wenqing Gao, et al.Science Translational Medicine|August 4, 2017
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancerDelphine Merino, James R Whittle, François Vaillant, et al.Nature Communications|June 23, 2018
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosisEmma J Petrie, Jarrod J Sandow, Annette V Jacobsen, et al.Cell Reports|September 26, 2019
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3Emma J Petrie, Jarrod J Sandow, Wil I L Lehmann, et al.Pageof 9