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Nature Immunology|November 27, 2023
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune systemMartin W LaFleur, Ashlyn M Lemmen, Ivy S L Streeter, et al.Molecular Cell|June 11, 2013
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylaseGaëlle Laurent, Natalie J German, Asish K Saha, et al.Cell|August 9, 2024
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicityShin Foong Ngiow, Sasikanth Manne, Yinghui Jane Huang, et al.The Journal of Experimental Medicine|October 12, 2020
PD-1 restraint of regulatory T cell suppressive activity is critical for immune toleranceCatherine L Tan, Juhi R Kuchroo, Peter T Sage, et al.Nature Immunology|February 27, 2001
PD-L2 is a second ligand for PD-1 and inhibits T cell activationY Latchman, C R Wood, T Chernova, et al.Journal of Translational Autoimmunity|August 4, 2020
Programmed death ligand 2 - A link between inflammation and bone loss in rheumatoid arthritisStinne R Greisen, Tue W Kragstrup, Jesper Skovhus Thomsen, et al.Proceedings of the National Academy of Sciences of the United States of America|April 8, 2026
Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infectionMasao Hashimoto, Tahseen H Nasti, Hyun-Tak Jin, et al.Cancer Immunology Research|November 8, 2015
Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent ModelDavid A Reardon, Prafulla C Gokhale, Sarah R Klein, et al.Science (New York, N.Y.)|March 11, 2017
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependentAlice O Kamphorst, Andreas Wieland, Tahseen Nasti, et al.The Journal of Experimental Medicine|July 24, 2025
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashionKristen E Pauken, Samuel C Markson, Thomas S Conway, et al.Pageof 42