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Molecular Cell|April 10, 2025
MLKL activity requires a splicing-regulated, druggable intramolecular interactionUris Ros, Veronica Martinez-Osorio, Pedro A Valiente, et al.EMBO Molecular Medicine|June 16, 2021
Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19Sebastian J Theobald, Alexander Simonis, Theodoros Georgomanolis, et al.Proceedings of the National Academy of Sciences of the United States of America|October 7, 2009
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancerMartin L Sos, Stefanie Fischer, Roland Ullrich, et al.Nature Communications|December 18, 2025
Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progressionAriadne Androulidaki, Fanyu Liu, Christina M Bebber, et al.Blood|April 23, 2026
Expression of cFLIP in B cells is essential for diffuse large B-cell lymphoma pathogenesisKristie Tanavura Bariboloka, Santiago Serrano-Saenz, Deniz Pinar Savcigil, et al.Journal of Hepatology|June 30, 2020
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytesSandra Lampl, Marianne K Janas, Sainitin Donakonda, et al.Blood Cancer Discovery|January 15, 2021
An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular VulnerabilitiesRuth Flümann, Tim Rehkämper, Pascal Nieper, et al.Immunity|February 9, 2022
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathwayDaniel S Simpson, Jiyi Pang, Ashley Weir, et al.Nature Neuroscience|October 22, 2021
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cellsJan Wenzel, Josephine Lampe, Helge Müller-Fielitz, et al.Nature|December 13, 2019
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory diseaseNajoua Lalaoui, Steven E Boyden, Hirotsugu Oda, et al.Pageof 25