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The International Journal of Neuropsychopharmacology|July 11, 2026
PDE4A Knockdown Rescues Alcohol-Induced Cognitive Impairment and Synaptic Dysfunction via the cAMP/PKA/CREB PathwayHuan Tu, Rongzhen Sun, Shengyao Ma, et al.International Immunopharmacology|May 3, 2024
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in miceWei Zhao, Shuang Zhao, Ran Wei, et al.RSC Medicinal Chemistry|April 26, 2024
Discovery of novel positive allosteric modulators targeting GluN1/2A NMDARs as anti-stroke therapeutic agentsHongyu Zhu, Xin Chen, Lu Zhang, et al.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|April 29, 2004
Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampusHan-Ting Zhang, Yu Zhao, Ying Huang, et al.Acta Pharmacologica Sinica|February 6, 2026
PDE4 inhibitor rolipram dynamically regulates the balance between D1-MSNs and D2-MSNs in the DMS to modulate abnormal "Go" behavior associated with alcohol addictionWei Zhao, Shuang Zhao, Zi-Qi Wang, et al.Metabolic Brain Disease|August 24, 2019
Adjuvant therapy with Astragalus membranaceus for post-stroke fatigue: a systematic reviewLi Xu, Xiao-Yan Xu, Xue-Qin Hou, et al.Cellular Signalling|June 7, 2026
Phosphodiesterase 8 (PDE8), a novel target for neurodegenerative diseasesXuan Zhao, Yi-Ting Fu, Nian-Zhuang Qiu, et al.Journal of Alzheimer'S Disease : JAD|August 17, 2013
RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-β42-induced memory deficits in miceCong Zhang, Yufang Cheng, Haitao Wang, et al.Psychopharmacology|April 22, 2011
Inhibition of phosphodiesterase-4 decreases ethanol intake in miceWei Hu, Tina Lu, Alan Chen, et al.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|June 12, 2009
Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampusYun-Feng Li, Ying Huang, Simon L Amsdell, et al.Pageof 12