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Journal of Pharmacokinetics and Pharmacodynamics|April 7, 2012
The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type ratLeon M Tai, Helmut Jacobsen, Laurence Ozmen, et al.
Journal of Pharmaceutical Sciences|July 29, 2019
PKPD Assessment of the Anti-CD20 Antibody Obinutuzumab in Cynomolgus Monkey is Feasible Despite Marked Anti-Drug Antibody Response in This SpeciesHans Peter Grimm, Eginhard Schick, Dominik Hainzl, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 24, 2008
Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro modelAgnès Poirier, Thierry Lavé, Renée Portmann, et al.
CPT: Pharmacometrics & Systems Pharmacology|November 23, 2022
Learn-confirm in model-informed drug development: Assessing an immunogenicity quantitative systems pharmacology platformLinnea C Franssen, Maciej J Swat, Andrzej M Kierzek, et al.
The AAPS Journal|April 5, 2020
Subcutaneous Site-of-Absorption Study with the Monoclonal Antibody Tocilizumab in Minipigs: Administration Behind Ear Translates Best to HumansWolfgang F Richter, Hans-Peter Grimm, Marie-Hélène Gouy, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|February 22, 2018
Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer ImmunotherapyBenjamin Ribba, Christophe Boetsch, Tapan Nayak, et al.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association|December 1, 2022
Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model)Norman A Mazer, Carsten Hofmann, Dominik Lott, et al.
Alzheimer'S & Dementia (New York, N. Y.)|June 9, 2022
In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic modelRoxana Aldea, Hans Peter Grimm, Ronald Gieschke, et al.
Birth Defects Research. Part B, Developmental and Reproductive Toxicology|March 27, 2013
The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile miceTakayuki Sakurai, Ryo Takai, Heinrich Bürgin, et al.
Mabs|August 9, 2013
Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeysVladimir Vexler, Li Yu, Chandrasena Pamulapati, et al.
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