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Toxicology|December 2, 2023
Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteineJephte Y Akakpo, Anup Ramachandran, Barry H Rumack, et al.
Archives of Toxicology|January 3, 2022
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdoseJephte Y Akakpo, Anup Ramachandran, Steven C Curry, et al.
Biochemical Pharmacology|February 12, 2024
Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failureAnup Ramachandran, Jephte Y Akakpo, Steven C Curry, et al.
Archives of Toxicology|November 1, 2021
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in miceNga T Nguyen, David S Umbaugh, Giselle Sanchez-Guerrero, et al.
Toxicology|April 13, 2024
The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regenerationDavid S Umbaugh, Nga T Nguyen, Sawyer H Smith, et al.
Archives of Toxicology|August 16, 2025
Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in miceOlamide B Adelusi, Caitlin Schneider, Caylie McKimens, et al.
Toxicology and Applied Pharmacology|December 7, 2019
Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicityLuqi Duan, Anup Ramachandran, Jephte Y Akakpo, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|September 19, 2012
Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activationYuchao Xie, C David Williams, Mitchell R McGill, et al.
Archives of Toxicology|March 29, 2024
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in miceOlamide B Adelusi, Jephte Y Akakpo, Gary Eichenbaum, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|August 27, 2016
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and DysfunctionKuo Du, Anup Ramachandran, James L Weemhoff, et al.
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