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Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 18, 2013
Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonistHarvey Wong, Stephen E Gould, Nageshwar Budha, et al.ACS Medicinal Chemistry Letters|August 25, 2020
Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target ActivityJames J Crawford, Wendy Lee, Adam R Johnson, et al.Drug Discovery Today|May 7, 2017
Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspectiveHarvey Wong, Tonika Bohnert, Valeriu Damian-Iordache, et al.Toxicological Sciences : an Official Journal of the Society of Toxicology|July 31, 2012
Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysisHarvey Wong, Nageshwar R Budha, Kristina West, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 16, 2013
Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processingXingrong Liu, Harvey Wong, Kimberly Scearce-Levie, et al.Journal of Medicinal Chemistry|April 14, 2009
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonistsPaul J Gilligan, Liqi He, Todd Clarke, et al.Journal of Medicinal Chemistry|April 14, 2009
Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonistsPaul J Gilligan, Todd Clarke, Liqi He, et al.The Journal of Pharmacology and Experimental Therapeutics|November 9, 2016
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in RatsRebecca I Erickson, Leah K Schutt, Jacqueline M Tarrant, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 12, 2011
Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitorLichuan Liu, Jason S Halladay, Young Shin, et al.Bioorganic & Medicinal Chemistry Letters|July 4, 2012
Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonistsCarolyn D Dzierba, Thais M Sielecki, Argyrios G Arvanitis, et al.Pageof 11