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Chimia
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September 15, 2021
Contribution to the Discovery of a Novel Medicine for a Neuromuscular Disease and of other Promising Molecules for the Treatment of Neurodevelopmental and Neurodegenerative Diseases
Hasane Ratni
Progress in Medicinal Chemistry
|
March 19, 2019
Rewriting the (tran)script: Application to spinal muscular atrophy
Hasane Ratni, Lutz Mueller, Martin Ebeling
ACS Medicinal Chemistry Letters
|
June 18, 2021
Risdiplam, the First Approved Small Molecule Splicing Modifier Drug as a Blueprint for Future Transformative Medicines
Hasane Ratni, Renata S Scalco, Alexander H Stephan
Journal of Medicinal Chemistry
|
October 13, 2009
Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures
Pari Malherbe, Claudia Kratzeisen, Anne Marcuz, et al.
Molecular Pharmacology
|
March 1, 2008
Me-talnetant and osanetant interact within overlapping but not identical binding pockets in the human tachykinin neurokinin 3 receptor transmembrane domains
Pari Malherbe, Caterina Bissantz, Anne Marcuz, et al.
Neuropharmacology
|
August 10, 2014
Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization
Pari Malherbe, Frédéric Knoflach, Anne Marcuz, et al.
Journal of Medicinal Chemistry
|
February 6, 2015
Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach
Hasane Ratni, Mark Rogers-Evans, Caterina Bissantz, et al.
Nature Chemical Biology
|
October 23, 2019
Structural basis of a small molecule targeting RNA for a specific splicing correction
Sébastien Campagne, Sarah Boigner, Simon Rüdisser, et al.
Journal of Medicinal Chemistry
|
April 26, 2017
Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy
Emmanuel Pinard, Luke Green, Michael Reutlinger, et al.
Nature Communications
|
May 30, 2026
Tunable gene control via RNA splicing with a clinically approved small molecule
Mateusz Mendel, Dominic Schwarz, Tao Sun, et al.
Page
of 3
Search research articles
Search
Showing results (1-10 of 24) with videos related to
Sort By:
Page
of 3
Chimia
|
September 15, 2021
Contribution to the Discovery of a Novel Medicine for a Neuromuscular Disease and of other Promising Molecules for the Treatment of Neurodevelopmental and Neurodegenerative Diseases
Hasane Ratni
Progress in Medicinal Chemistry
|
March 19, 2019
Rewriting the (tran)script: Application to spinal muscular atrophy
Hasane Ratni, Lutz Mueller, Martin Ebeling
ACS Medicinal Chemistry Letters
|
June 18, 2021
Risdiplam, the First Approved Small Molecule Splicing Modifier Drug as a Blueprint for Future Transformative Medicines
Hasane Ratni, Renata S Scalco, Alexander H Stephan
Journal of Medicinal Chemistry
|
October 13, 2009
Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures
Pari Malherbe, Claudia Kratzeisen, Anne Marcuz, et al.
Molecular Pharmacology
|
March 1, 2008
Me-talnetant and osanetant interact within overlapping but not identical binding pockets in the human tachykinin neurokinin 3 receptor transmembrane domains
Pari Malherbe, Caterina Bissantz, Anne Marcuz, et al.
Neuropharmacology
|
August 10, 2014
Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization
Pari Malherbe, Frédéric Knoflach, Anne Marcuz, et al.
Journal of Medicinal Chemistry
|
February 6, 2015
Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach
Hasane Ratni, Mark Rogers-Evans, Caterina Bissantz, et al.
Nature Chemical Biology
|
October 23, 2019
Structural basis of a small molecule targeting RNA for a specific splicing correction
Sébastien Campagne, Sarah Boigner, Simon Rüdisser, et al.
Journal of Medicinal Chemistry
|
April 26, 2017
Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy
Emmanuel Pinard, Luke Green, Michael Reutlinger, et al.
Nature Communications
|
May 30, 2026
Tunable gene control via RNA splicing with a clinically approved small molecule
Mateusz Mendel, Dominic Schwarz, Tao Sun, et al.
Page
of 3