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Science Advances|August 30, 2024
Discovery of SARS-CoV-2 papain-like protease (PL<sup>pro</sup>) inhibitors with efficacy in a murine infection modelMichelle R Garnsey, Matthew C Robinson, Luong T Nguyen, et al.Journal of Medicinal Chemistry|February 22, 2018
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK)David J Edmonds, Daniel W Kung, Amit S Kalgutkar, et al.Nature Communications|January 2, 2025
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variantsMichelle R Garnsey, Yang Wang, David J Edmonds, et al.Science (New York, N.Y.)|November 2, 2021
An oral SARS-CoV-2 M<sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, et al.Biorxiv : the Preprint Server for Biology|September 16, 2020
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19Britton Boras, Rhys M Jones, Brandon J Anson, et al.Nature Communications|October 19, 2021
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19Britton Boras, Rhys M Jones, Brandon J Anson, et al.Journal of Medicinal Chemistry|April 30, 2024
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19Charlotte M N Allerton, Joel T Arcari, Lisa M Aschenbrenner, et al.Journal of Medicinal Chemistry|February 28, 2025
Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main ProteaseJamison B Tuttle, Christophe Allais, Charlotte M N Allerton, et al.Pageof 8