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Leukemia & Lymphoma|August 28, 2010
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylationElizabeth A Griffiths, Steven D Gore, Craig Hooker, et al.Cancer Research|August 26, 2010
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleusHariharan P Easwaran, Leander Van Neste, Leslie Cope, et al.Bioorganic & Medicinal Chemistry Letters|May 7, 2025
Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degradersXuqing Zhang, Qiaolin Deng, Harshil Dhruv, et al.Molecular Cancer Research : MCR|November 10, 2019
Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in <i>PIK3CA</i>-Mutant Colorectal CancerSamuel A Miller, Robert A Policastro, Sudha S Savant, et al.Scientific Reports|December 18, 2020
Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissuesPaul B Noto, Timothy W Sikorski, Francesca Zappacosta, et al.Structure (London, England : 1993)|April 13, 2016
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding PocketsGlenn S Van Aller, Alan P Graves, Patricia A Elkins, et al.Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer|July 2, 2019
Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory SCLCTodd M Bauer, Benjamin Besse, Alex Martinez-Marti, et al.Journal of Medicinal Chemistry|August 22, 2025
Discovery of a Novel Series of <i>iso</i>-Indolinone-Based Glutarimides as Highly Efficacious and Selective IKZF2 Molecular Glue DegradersXuqing Zhang, Harshil Dhruv, Qiaolin Deng, et al.Nature Immunology|December 13, 2018
Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesisKaterina Hatzi, Huimin Geng, Ashley S Doane, et al.Journal of Medicinal Chemistry|November 21, 2024
Discovery of Potent, Highly Selective, and Efficacious SMARCA2 DegradersZhenwu Li, Lalgudi S Harikrishnan, Guozhang Xu, et al.Pageof 4