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Journal of Clinical Pharmacology|November 18, 2005
Pharmacokinetics of sirolimus (rapamycin) in subjects with mild to moderate hepatic impairmentJames J Zimmerman, Kenneth C Lasseter, Heng-Keang Lim, et al.
Chemical Research in Toxicology|March 26, 2024
Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover DrugsJackie Shang, Kevin J Coe, Heng Keang Lim, et al.
Journal of Pharmaceutical and Biomedical Analysis|August 17, 2013
LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volumeYaodong Xu, Yang Yuan, Lisa Smith, et al.
Bioorganic & Medicinal Chemistry|March 2, 2025
Biosynthesis and structure assignment of a hydroxylated metabolite of the orexin-1 receptor antagonist JNJ-61393215Fengbin Song, Jie Chen, Shannon Dallas, et al.
Journal of the American Society for Mass Spectrometry|January 17, 2025
Investigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry ImagingBryn Flinders, Lennart Huizing, Bhanu Singh, et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems|March 2, 2012
Free radical metabolism of raloxifene in human liver microsomesHeng-Keang Lim, Min Yang, Wing Lam, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|February 17, 2017
Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver InjuryMonicah A Otieno, Jan Snoeys, Wing Lam, et al.
Journal of Applied Toxicology : JAT|July 23, 2015
Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro modelLei Xia, Xin Hong, Rashidah Binte Sakban, et al.
Chemical Research in Toxicology|June 15, 2011
Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediateHeng-Keang Lim, Jie Chen, Carlo Sensenhauser, et al.
British Journal of Clinical Pharmacology|November 19, 2016
In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozinRao N V S Mamidi, Shannon Dallas, Carlo Sensenhauser, et al.
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