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Nature Aging|November 22, 2021
Dissociable effects of <i>APOE</i>-ε4 and β-amyloid pathology on visual working memoryKirsty Lu, Jennifer M Nicholas, Yoni Pertzov, et al.Journal of Medicinal Chemistry|December 20, 2019
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity TargetZoë A Henley, Augustin Amour, Nick Barton, et al.Journal of Medicinal Chemistry|April 5, 2023
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other MalignanciesA Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, et al.Ambio|October 10, 2021
Biogeochemical consequences of a changing Arctic shelf seafloor ecosystemChristian März, Felipe S Freitas, Johan C Faust, et al.Journal of Medicinal Chemistry|August 12, 2008
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activitiesKyoung Soon Kim, Liping Zhang, Robert Schmidt, et al.Oncotarget|August 22, 2015
The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphomaMike I Walton, Paul D Eve, Angela Hayes, et al.BMJ Open|August 8, 2025
Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative sourcesJosie Henley, Lucy Brookes-Howell, Philip Howard, et al.Journal of Medicinal Chemistry|September 11, 2018
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N<sup>2</sup>-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N<sup>8</sup>-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722)Hannah L Woodward, Paolo Innocenti, Kwai-Ming J Cheung, et al.Journal of Medicinal Chemistry|November 22, 2013
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)Sébastien Naud, Isaac M Westwood, Amir Faisal, et al.Journal of Medicinal Chemistry|April 8, 2016
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization ApproachPaolo Innocenti, Hannah L Woodward, Savade Solanki, et al.Pageof 191