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Nucleosides, Nucleotides & Nucleic Acids|October 21, 2003
Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activitySatoru Kohgo, Kohei Yamada, Kenji Kitano, et al.
The European Journal of Neuroscience|June 9, 2004
Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosineCandan Depboylu, Todd A Reinhart, Osamu Takikawa, et al.
ACS Medicinal Chemistry Letters|April 18, 2012
Design of substituted bis-Tetrahydrofuran (bis-THF)-derived Potent HIV-1 Protease Inhibitors, Protein-ligand X-ray Structure, and Convenient Syntheses of bis-THF and Substituted bis-THF LigandsArun K Ghosh, Cuthbert D Martyr, Melinda Steffey, et al.
Journal of Medicinal Chemistry|January 4, 2011
Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluationArun K Ghosh, Bruno D Chapsal, Abigail Baldridge, et al.
Antimicrobial Agents and Chemotherapy|May 5, 2010
Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitroYasushi Tojo, Yasuhiro Koh, Masayuki Amano, et al.
Internal Medicine (Tokyo, Japan)|September 16, 2016
Successful Treatment of Amyloid Light-chain Amyloidosis in a Charcot-Marie-Tooth Disease Patient with Lenalidomide, Cyclophosphamide, and DexamethasoneYoshitaka Kikukawa, Hiroyuki Hata, Mitsuharu Ueda, et al.
Antimicrobial Agents and Chemotherapy|October 29, 2008
GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitroYasuhiro Koh, Debananda Das, Sofiya Leschenko, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 6, 2014
Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavirHironori Hayashi, Nobutoki Takamune, Takashi Nirasawa, et al.
Free Radical Biology & Medicine|August 27, 2013
Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathwayManabu Taura, Ryusho Kariya, Eriko Kudo, et al.
Antimicrobial Agents and Chemotherapy|January 3, 2022
Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In VitroMasayuki Amano, Ravikiran S Yedidi, Pedro Miguel Salcedo-Gómez, et al.
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