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Cancer Science|January 27, 2026
IAP Antagonists Selectively Eliminate Therapy-Induced Senescent Cancer Cells via TNFα-Independent ApoptosisHiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, et al.
Cancer Science|October 5, 2019
Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathwaysHiromi Muraoka, Chihoko Yoshimura, Rumi Kawabata, et al.
Molecular Cancer Therapeutics|May 17, 2019
TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer ModelsChihoko Yoshimura, Hiromi Muraoka, Hiroaki Ochiiwa, et al.
Cancer Research|September 25, 2020
Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated TumorsHiroshi Sootome, Hidenori Fujita, Kenjiro Ito, et al.
Oncogene|January 9, 2021
TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemiaHiroaki Ochiiwa, Guzhanuer Ailiken, Masataka Yokoyama, et al.
Cell Death Discovery|July 2, 2024
The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activityTakeshi Wakasa, Kentaro Nonaka, Akihito Harada, et al.
Molecular Cancer Therapeutics|October 22, 2013
The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profileHidenori Fujita, Kazutaka Miyadera, Masanori Kato, et al.
International Journal of Clinical Oncology|March 24, 2023
Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro FujiiYoshihiko Maehara, Eiji Oki, Mitsuhiko Ota, et al.
Journal of Medicinal Chemistry|March 11, 2024
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2)James E H Day, Valerio Berdini, Joan Castro, et al.
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