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Pharmacology, Biochemistry, and Behavior|October 27, 2019
TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in miceHiroshi Yukitake, Tatsuhiko Fujimoto, Takashi Ishikawa, et al.
Chemistry & Biology|December 21, 2010
BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expressionHaruhide Kimura, Yoshimi Sato, Yasukazu Tajima, et al.
Chemistry & Biology|February 10, 2010
ITZ-1, a client-selective Hsp90 inhibitor, efficiently induces heat shock factor 1 activationHaruhide Kimura, Hiroshi Yukitake, Yasukazu Tajima, et al.
Journal of Sleep Research|March 19, 2023
Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individualsRebecca Evans, Haruhide Kimura, Masato Nakashima, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 22, 2022
Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patientsRebecca Evans, Haruhide Kimura, Robert Alexander, et al.
Human Molecular Genetics|June 13, 2018
Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neuronsAkiko Sumitomo, Hiroshi Yukitake, Kazuko Hirai, et al.
Molecular Psychiatry|November 11, 2020
From population to neuron: exploring common mediators for metabolic problems and mental illnessesYoichiro Takayanagi, Koko Ishizuka, Thomas M Laursen, et al.
ACS Medicinal Chemistry Letters|March 17, 2022
Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor AgonistTatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, et al.
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