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Bioorganic & Medicinal Chemistry Letters|April 24, 2018
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemiaMakoto Hamada, Tetsuo Takayama, Tsuyoshi Shibata, et al.Journal of Medicinal Chemistry|June 10, 2022
Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary FibrosisTomoki Takeuchi, Masato Hayashi, Tomoko Tamita, et al.European Journal of Medicinal Chemistry|August 28, 2023
Lead generation from N-[benzyl(4-phenylbutyl)carbamoyl]amino acid as a novel LPA<sub>1</sub> antagonist for the treatment of systemic sclerosisYuki Kobayashi, Fumito Uneuchi, Takumi Naruse, et al.Journal of Molecular Biology|September 2, 2003
High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activitySergey N Ruzheinikov, Tatyana A Muranova, Svetlana E Sedelnikova, et al.Bioorganic & Medicinal Chemistry Letters|March 29, 2022
Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitorsYasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, et al.Bioorganic & Medicinal Chemistry Letters|January 23, 2022
Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitorsYasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, et al.Bioorganic & Medicinal Chemistry|May 16, 2022
Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitorsYasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, et al.Journal of Medicinal Chemistry|November 1, 2022
Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 InhibitionMadoka Kawamura, Yohei Kobashi, Hiroaki Tanaka, et al.Bioorganic & Medicinal Chemistry|November 4, 2024
Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2Madoka Kawamura, Yohei Kobashi, Hiroaki Tanaka, et al.Journal of Medicinal Chemistry|March 23, 2010
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatmentHiroyuki Kakinuma, Takahiro Oi, Yuko Hashimoto-Tsuchiya, et al.Pageof 4