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The Analyst|December 15, 2010
Antibody engineering toward high-sensitivity high-throughput immunosensing of small moleculesNorihiro Kobayashi, Hiroyuki OyamaYakugaku Zasshi : Journal of the Pharmaceutical Society of Japan|January 5, 2007
[Antibody engineering-based approach for hapten immunometric assays with high sensitivity]Norihiro Kobayashi, Yoshinori Kato, Hiroyuki Oyama, et al.Analytical Chemistry|May 2, 2013
"Breeding" diagnostic antibodies for higher assay performance: a 250-fold affinity-matured antibody mutant targeting a small biomarkerHiroyuki Oyama, Shuko Yamaguchi, Shigetoshi Nakata, et al.NAR Molecular Medicine|July 22, 2026
Acyclic artificial nucleic acid substitution expands the safe design space of gapmer ASOs by preventing P54nrb mislocalizationJumpei Ariyoshi, Masaya Higuchi, Hiroyuki Oyama, et al.Scientific Reports|April 16, 2021
The VH framework region 1 as a target of efficient mutagenesis for generating a variety of affinity-matured scFv mutantsYuki Kiguchi, Hiroyuki Oyama, Izumi Morita, et al.Analytica Chimica Acta|March 21, 2009
An enzyme-linked immunometric assay for cortisol based on idiotype-anti-idiotype reactionsToshifumi Niwa, Takayuki Kobayashi, Pi Sun, et al.Analytical Chemistry|May 13, 2010
Oligosaccharide-assisted direct immunosensing of small moleculesNorihiro Kobayashi, Hiroyuki Oyama, Iwao Suzuki, et al.Analytical Chemistry|November 22, 2013
Anti-idiotype scFv-enzyme fusion proteins: a clonable analyte-mimicking probe for standardized immunoassays targeting small biomarkersHiroyuki Oyama, Eri Tanaka, Tomoyo Kawanaka, et al.Acta Crystallographica. Section C, Crystal Structure Communications|February 8, 2005
Tetra-n-butylammonium bromide-water (1/38)Wataru Shimada, Motoo Shiro, Hidemasa Kondo, et al.Analytical Chemistry|January 6, 2010
Two-step in vitro antibody affinity maturation enables estradiol-17beta assays with more than 10-fold higher sensitivityNorihiro Kobayashi, Hiroyuki Oyama, Yoshinori Kato, et al.Pageof 4