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Angewandte Chemie (International Ed. in English)|June 29, 2021
Dendritically Cross-Linking Chiral Ligands: High Stability of a Polystyrene-Bound Ti-TADDOLate Catalyst with Diffusion ControlHolger Sellner, Dieter SeebachBioorganic & Medicinal Chemistry Letters|March 19, 2015
trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linkerEdwige Lorthiois, Frederic Cumin, Claus Ehrhardt, et al.Bioorganic & Medicinal Chemistry Letters|March 11, 2015
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linkerHolger Sellner, Sylvain Cottens, Frédéric Cumin, et al.Journal of Medicinal Chemistry|February 22, 2013
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searchesEdwige Lorthiois, Werner Breitenstein, Frederic Cumin, et al.Bioorganic & Medicinal Chemistry Letters|February 14, 2018
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitorsKenji Namoto, Finton Sirockin, Holger Sellner, et al.Chemmedchem|August 11, 2022
The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct CompetitionPascal Furet, Vincent Bordas, Mickaël Le Douget, et al.Journal of Medicinal Chemistry|March 4, 2026
Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI DisrupterMarkus Vögtle, Holger Sellner, Emilie Chapeau, et al.Chemmedchem|March 29, 2023
Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction InhibitorsHolger Sellner, Emilie Chapeau, Pascal Furet, et al.Human Molecular Genetics|August 9, 2022
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degenerationMaura A Crowley, Donita L Garland, Holger Sellner, et al.Nature Cancer|April 2, 2024
Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancersEmilie A Chapeau, Laurent Sansregret, Giorgio G Galli, et al.Pageof 2