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European Journal of Medicinal Chemistry
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July 2, 2025
Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models
Baljit Kaur, Hossam Nada, Longfei Zhang, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|
December 20, 2025
Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential
Saurabh Upadhyay, Hossam Nada, Sungwoo Cho, et al.
Journal of Medicinal Chemistry
|
November 21, 2025
Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-Stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation
Saurabh Upadhyay, Sungwoo Cho, Hossam Nada, et al.
European Journal of Medicinal Chemistry
|
July 15, 2025
CHI3L1-targeted small molecules as glioblastoma therapies: Virtual screening-based discovery, biophysical validation, pharmacokinetic profiling, and evaluation in glioblastoma spheroids
Hossam Nada, Longfei Zhang, Baljit Kaur, et al.
Biorxiv : the Preprint Server for Biology
|
June 4, 2025
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids
Hossam Nada, Longfei Zhang, Baljit Kaur, et al.
European Journal of Medicinal Chemistry
|
May 14, 2025
First-in-class dual inhibitors of MASTL and Aurora A kinase: Discovery of selective cyclohexa[b]thiophenes with potent anticancer activity
Somaya A Abdel-Rahman, Hossam Nada, Moustafa T Gabr
Biorxiv : the Preprint Server for Biology
|
February 12, 2026
Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces
Hossam Nada, Sungwoo Cho, Ashraf N Abdo, et al.
Biorxiv : the Preprint Server for Biology
|
November 24, 2025
Structure-Guided Optimization and Functional Characterization of Small Molecule Antagonists Targeting CD28 Costimulation
Saurabh Upadhyay, Hossam Nada, Sungwoo Cho, et al.
Journal of Biomolecular Structure & Dynamics
|
January 13, 2023
Discovery and optimization of natural-based nanomolar c-Kit inhibitors via in silico and in vitro studies
Hossam Nada, Sungdo Kim, Sreenivasulu Godesi, et al.
ACS Omega
|
November 17, 2025
Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules
Laura Calvo-Barreiro, Hossam Nada, Saurabh Upadhyay, et al.
Page
of 8
Search research articles
Search
Showing results (21-30 of 79) with videos related to
Sort By:
Page
of 8
European Journal of Medicinal Chemistry
|
July 2, 2025
Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models
Baljit Kaur, Hossam Nada, Longfei Zhang, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|
December 20, 2025
Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential
Saurabh Upadhyay, Hossam Nada, Sungwoo Cho, et al.
Journal of Medicinal Chemistry
|
November 21, 2025
Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-Stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation
Saurabh Upadhyay, Sungwoo Cho, Hossam Nada, et al.
European Journal of Medicinal Chemistry
|
July 15, 2025
CHI3L1-targeted small molecules as glioblastoma therapies: Virtual screening-based discovery, biophysical validation, pharmacokinetic profiling, and evaluation in glioblastoma spheroids
Hossam Nada, Longfei Zhang, Baljit Kaur, et al.
Biorxiv : the Preprint Server for Biology
|
June 4, 2025
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids
Hossam Nada, Longfei Zhang, Baljit Kaur, et al.
European Journal of Medicinal Chemistry
|
May 14, 2025
First-in-class dual inhibitors of MASTL and Aurora A kinase: Discovery of selective cyclohexa[b]thiophenes with potent anticancer activity
Somaya A Abdel-Rahman, Hossam Nada, Moustafa T Gabr
Biorxiv : the Preprint Server for Biology
|
February 12, 2026
Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces
Hossam Nada, Sungwoo Cho, Ashraf N Abdo, et al.
Biorxiv : the Preprint Server for Biology
|
November 24, 2025
Structure-Guided Optimization and Functional Characterization of Small Molecule Antagonists Targeting CD28 Costimulation
Saurabh Upadhyay, Hossam Nada, Sungwoo Cho, et al.
Journal of Biomolecular Structure & Dynamics
|
January 13, 2023
Discovery and optimization of natural-based nanomolar c-Kit inhibitors via in silico and in vitro studies
Hossam Nada, Sungdo Kim, Sreenivasulu Godesi, et al.
ACS Omega
|
November 17, 2025
Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules
Laura Calvo-Barreiro, Hossam Nada, Saurabh Upadhyay, et al.
Page
of 8