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Alzheimer'S Research & Therapy
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February 4, 2018
Impact of amyloid-beta changes on cognitive outcomes in Alzheimer's disease: analysis of clinical trials using a quantitative systems pharmacology model
Hugo Geerts, Athan Spiros, Patrick Roberts
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|
May 5, 2021
Exploring the relation between BOLD fMRI and cognitive performance using a computer-based quantitative systems pharmacology model: Applications to the COMTVAL158MET genotype and ketamine
Hugo Geerts, Patrick Roberts, Athan Spiros
Journal of Alzheimer'S Disease Reports
|
December 30, 2021
Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer's Disease
Hugo Geerts, Piet van der Graaf
Frontiers in Pharmacology
|
February 13, 2016
A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease
Patrick Roberts, Athan Spiros, Hugo Geerts
Expert Review of Clinical Pharmacology
|
July 19, 2018
Use of quantitative clinical pharmacology to improve early clinical development success in neurodegenerative diseases
Hugo Geerts, Ronald Gieschke, Richard Peck
Frontiers in Pharmacology
|
November 7, 2014
A computer-based quantitative systems pharmacology model of negative symptoms in schizophrenia: exploring glycine modulation of excitation-inhibition balance
Athan Spiros, Patrick Roberts, Hugo Geerts
Alzheimer'S & Dementia (New York, N. Y.)
|
November 9, 2020
A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID-19
Hugo Geerts, Piet van der Graaf
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|
January 8, 2017
Semi-mechanistic computer simulation of psychotic symptoms in schizophrenia with a model of a humanized cortico-striatal-thalamocortical loop
Athan Spiros, Patrick Roberts, Hugo Geerts
Neuropsychiatric Disease and Treatment
|
September 22, 2010
Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse
Athan Spiros, Robert Carr, Hugo Geerts
Expert Review of Neurotherapeutics
|
December 6, 2016
Phosphodiesterase 10 inhibitors in clinical development for CNS disorders
Hugo Geerts, Athan Spiros, Patrick Roberts
Page
of 8
Search research articles
Search
Showing results (21-30 of 71) with videos related to
Sort By:
Page
of 8
Alzheimer'S Research & Therapy
|
February 4, 2018
Impact of amyloid-beta changes on cognitive outcomes in Alzheimer's disease: analysis of clinical trials using a quantitative systems pharmacology model
Hugo Geerts, Athan Spiros, Patrick Roberts
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|
May 5, 2021
Exploring the relation between BOLD fMRI and cognitive performance using a computer-based quantitative systems pharmacology model: Applications to the COMTVAL158MET genotype and ketamine
Hugo Geerts, Patrick Roberts, Athan Spiros
Journal of Alzheimer'S Disease Reports
|
December 30, 2021
Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer's Disease
Hugo Geerts, Piet van der Graaf
Frontiers in Pharmacology
|
February 13, 2016
A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease
Patrick Roberts, Athan Spiros, Hugo Geerts
Expert Review of Clinical Pharmacology
|
July 19, 2018
Use of quantitative clinical pharmacology to improve early clinical development success in neurodegenerative diseases
Hugo Geerts, Ronald Gieschke, Richard Peck
Frontiers in Pharmacology
|
November 7, 2014
A computer-based quantitative systems pharmacology model of negative symptoms in schizophrenia: exploring glycine modulation of excitation-inhibition balance
Athan Spiros, Patrick Roberts, Hugo Geerts
Alzheimer'S & Dementia (New York, N. Y.)
|
November 9, 2020
A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID-19
Hugo Geerts, Piet van der Graaf
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|
January 8, 2017
Semi-mechanistic computer simulation of psychotic symptoms in schizophrenia with a model of a humanized cortico-striatal-thalamocortical loop
Athan Spiros, Patrick Roberts, Hugo Geerts
Neuropsychiatric Disease and Treatment
|
September 22, 2010
Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse
Athan Spiros, Robert Carr, Hugo Geerts
Expert Review of Neurotherapeutics
|
December 6, 2016
Phosphodiesterase 10 inhibitors in clinical development for CNS disorders
Hugo Geerts, Athan Spiros, Patrick Roberts
Page
of 8