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Pharmacology Research & Perspectives|September 24, 2020
Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte modelBaoXi Gao, Weston Sutherland, Hugo M Vargas, et al.Frontiers in Cardiovascular Medicine|March 12, 2021
The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus MonkeyMichael J Engwall, Nancy Everds, James R Turk, et al.Clinical and Translational Science|May 6, 2021
Comprehensive in vitro pro-arrhythmic assays demonstrate that omecamtiv mecarbil has low pro-arrhythmic riskYusheng Qu, BaoXi Gao, Ziva Arimura, et al.Clinical Pharmacology and Therapeutics|February 16, 2024
Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low-Risk Modalities?Yusheng Qu, Kim A Henderson, Tod A Harper, et al.Journal of Pharmacological and Toxicological Methods|June 3, 2021
Validation of using cardioplegic solutions for preserving cardiac function in isolated rabbit heart assaysZiva Arimura, BaoXi Gao, Mei Fang, et al.The Journal of Pharmacology and Experimental Therapeutics|January 6, 2011
BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heartYusheng Qu, Mei Fang, Baoxi Gao, et al.Journal of Pharmacological and Toxicological Methods|May 21, 2013
Safety pharmacology investigations in toxicology studies: an industry surveySimon Authier, Hugo M Vargas, Michael J Curtis, et al.Journal of Pharmacological and Toxicological Methods|July 7, 2020
Inotropic assessment in engineered 3D cardiac tissues using human induced pluripotent stem cell-derived cardiomyocytes in the BiowireTM II platformYusheng Qu, Nicole Feric, Isabella Pallotta, et al.Journal of Pharmacological and Toxicological Methods|June 17, 2018
Decreased contractility and altered responses to inotropic agents in myocytes from tachypacing-induced heart failure caninesBaoXi Gao, Yusheng Qu, Weston Sutherland, et al.Journal of Pharmacological and Toxicological Methods|June 11, 2025
Results from an EFPIA, JPMA, PhRMA industry survey on reopening and revamping the ICH S7A guidance on safety and secondary pharmacologyJean-Pierre Valentin, Katsuyoshi Chiba, Derek Leishman, et al.Pageof 7