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Journal of Pharmacological and Toxicological Methods|March 30, 2023
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substituteHugo M Vargas, Eric I Rossman, Todd A Wisialowski, et al.Bioorganic & Medicinal Chemistry Letters|July 5, 2005
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomniaL Rebecca Fish, Myra T Gilligan, Alexander C Humphries, et al.Journal of Pharmacological and Toxicological Methods|June 7, 2016
Safety pharmacology investigations on the nervous system: An industry surveySimon Authier, Joseph Arezzo, Marcus S Delatte, et al.Journal of Pharmacological and Toxicological Methods|May 12, 2015
The Diplomate in Safety Pharmacology (DSP) certification schemeSimon Authier, Michael J Curtis, Maxim Soloviev, et al.Medchemcomm|August 16, 2018
Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin DJonathan D Low, Michael D Bartberger, Kui Chen, et al.Toxicologic Pathology|May 4, 2012
Off-target platelet activation in macaques unique to a therapeutic monoclonal antibodyMichael J Santostefano, Jacqueline Kirchner, Christine Vissinga, et al.Journal of Pharmacological and Toxicological Methods|May 30, 2008
Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologicsHugo M Vargas, Alan S Bass, Alexander Breidenbach, et al.Toxicological Sciences : an Official Journal of the Society of Toxicology|September 24, 2014
The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiativeLorna Ewart, Mike Aylott, Mark Deurinck, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MSAshis K Saha, Xiang Yu, Jian Lin, et al.Journal of Pharmacological and Toxicological Methods|May 10, 2023
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&AsEric I Rossman, Todd A Wisialowski, Hugo M Vargas, et al.Pageof 7