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Molecular Pharmacology|June 14, 2023
Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA ReceptorHugo R Arias, Spencer R Pierce, Allison L Germann, et al.
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology|July 8, 2021
Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activationKatarzyna M Targowska-Duda, Barbara Budzynska, Agnieszka Michalak, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|February 12, 2025
Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptorsHugo R Arias, Laura Micheli, Anders A Jensen, et al.
Biochemical Pharmacology|February 14, 2026
Ibogalogs induce antiseizure activity in rodents by a mechanism involving 5-HT2A/2C receptor activation with a major role of 5-HT2A receptors in the hippocampal CA3 subfieldAbdeslam Chagraoui, Paulina Kazmierska-Grebowska, Olivia Byache, et al.
European Journal of Pharmacology|January 22, 2024
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activationHugo R Arias, Deborah Rudin, Dustin J Hines, et al.
Biochemical Pharmacology|March 19, 2022
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loopHugo R Arias, Cecilia M Borghese, Allison L Germann, et al.
ACS Chemical Neuroscience|October 19, 2020
(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor PotentiationHugo R Arias, Carla Ghelardini, Elena Lucarini, et al.
Neurochemistry International|June 5, 2024
Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic CortexKassandra Looschen, Shailesh Narayan Khatri, Malabika Maulik, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|June 18, 2024
Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activationHugo R Arias, Laura Micheli, Deborah Rudin, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|November 12, 2025
Ibogalogs improve spatial and recognition memory in rodents through a mechanism involving 5-HT2A receptor activation-enhanced NMDA receptor activity in hippocampal pyramidal CA1 neuronsAbdeslam Chagraoui, Luis A Haro Santillan, Renata Bocian, et al.
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