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I Carruthers

Showing results (81-90 of 96) with videos related to

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ACS Medicinal Chemistry Letters|June 6, 2014
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 AntagonistsMichael A Letavic, Brian Lord, Francois Bischoff, et al.
The Journal of Pharmacology and Experimental Therapeutics|July 17, 2015
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of InsomniaPascal Bonaventure, Jonathan Shelton, Sujin Yun, et al.
Journal of Medicinal Chemistry|February 9, 2023
Discovery of a Series of Substituted 1<i>H</i>-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric ModulatorsChristine F Gelin, Brice Stenne, Heather Coate, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|March 25, 2005
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer painJoseph R Ghilardi, Heidi Röhrich, Theodore H Lindsay, et al.
Journal of Medicinal Chemistry|June 19, 2015
Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical CandidateMichael A Letavic, Pascal Bonaventure, Nicholas I Carruthers, et al.
ACS Medicinal Chemistry Letters|August 22, 2018
Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8Suchitra Ravula, Brad M Savall, Nyantsz Wu, et al.
Bioorganic & Medicinal Chemistry Letters|April 13, 2010
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonistsEmily M Stocking, Leah Aluisio, John R Atack, et al.
Journal of Medicinal Chemistry|December 7, 2017
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical CandidateChrista C Chrovian, Akinola Soyode-Johnson, Alexander A Peterson, et al.
Journal of Medicinal Chemistry|September 5, 2003
The first potent and selective non-imidazole human histamine H4 receptor antagonistsJill A Jablonowski, Cheryl A Grice, Wenying Chai, et al.
Journal of Medicinal Chemistry|August 23, 2016
Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptorDevin M Swanson, Brad M Savall, Kevin J Coe, et al.
Pageof 10

Showing results (81-90 of 96) with videos related to

Sort By:
Pageof 10
ACS Medicinal Chemistry Letters|June 6, 2014
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 AntagonistsMichael A Letavic, Brian Lord, Francois Bischoff, et al.
The Journal of Pharmacology and Experimental Therapeutics|July 17, 2015
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of InsomniaPascal Bonaventure, Jonathan Shelton, Sujin Yun, et al.
Journal of Medicinal Chemistry|February 9, 2023
Discovery of a Series of Substituted 1<i>H</i>-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric ModulatorsChristine F Gelin, Brice Stenne, Heather Coate, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|March 25, 2005
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer painJoseph R Ghilardi, Heidi Röhrich, Theodore H Lindsay, et al.
Journal of Medicinal Chemistry|June 19, 2015
Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical CandidateMichael A Letavic, Pascal Bonaventure, Nicholas I Carruthers, et al.
ACS Medicinal Chemistry Letters|August 22, 2018
Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8Suchitra Ravula, Brad M Savall, Nyantsz Wu, et al.
Bioorganic & Medicinal Chemistry Letters|April 13, 2010
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonistsEmily M Stocking, Leah Aluisio, John R Atack, et al.
Journal of Medicinal Chemistry|December 7, 2017
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical CandidateChrista C Chrovian, Akinola Soyode-Johnson, Alexander A Peterson, et al.
Journal of Medicinal Chemistry|September 5, 2003
The first potent and selective non-imidazole human histamine H4 receptor antagonistsJill A Jablonowski, Cheryl A Grice, Wenying Chai, et al.
Journal of Medicinal Chemistry|August 23, 2016
Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptorDevin M Swanson, Brad M Savall, Kevin J Coe, et al.
Pageof 10