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Journal of Medicinal Chemistry|April 10, 2019
Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE<sub>1</sub> Series EP<sub>4</sub> Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE<sub>1</sub> Analog (KMN-159) as a Potent EP<sub>4</sub> AgonistStephen D Barrett, Melissa C Holt, James B Kramer, et al.Pageof 11