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Journal of Biomolecular Screening|January 2, 2014
Lead discovery for human kynurenine 3-monooxygenase by high-throughput RapidFire mass spectrometryDenise M Lowe, Michelle Gee, Carl Haslam, et al.Journal of Medicinal Chemistry|July 8, 2005
Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an "agreement docking" methodMike Barker, Margaret Clackers, Derek A Demaine, et al.Nature Communications|June 13, 2017
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenaseJonathan P Hutchinson, Paul Rowland, Mark R D Taylor, et al.Bioorganic & Medicinal Chemistry Letters|July 10, 2007
Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimeticsMargaret Clackers, Diane M Coe, Derek A Demaine, et al.Bioorganic & Medicinal Chemistry Letters|March 6, 2010
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonistJoseph Rimland, Angela Dunne, Suchete S Hunjan, et al.Journal of Medicinal Chemistry|February 29, 2020
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen PresentationJohn Liddle, Jonathan P Hutchinson, Semra Kitchen, et al.Journal of Medicinal Chemistry|November 28, 2007
Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivityKeith Biggadike, Mohamed Boudjelal, Margaret Clackers, et al.Journal of Medicinal Chemistry|April 12, 2017
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute PancreatitisAnn L Walker, Nicolas Ancellin, Benjamin Beaufils, et al.Cell Reports|July 21, 2023
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitisAlastair J Hayes, Xiaozhong Zheng, James O'Kelly, et al.Journal of Medicinal Chemistry|July 11, 2006
Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine seriesMike Barker, Margaret Clackers, Royston Copley, et al.Pageof 3