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Journal of Medicinal Chemistry
|
July 19, 2023
Determination of Ligand-Binding Affinity (<i>K</i><sub>d</sub>) Using Transverse Relaxation Rate (<i>R</i><sub>2</sub>) in the Ligand-Observed <sup>1</sup>H NMR Experiment and Applications to Fragment-Based Drug Discovery
Manjuan Liu, Amin Mirza, P Craig McAndrew, et al.
Bioorganic & Medicinal Chemistry
|
October 27, 2005
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
Ian Collins, John Caldwell, Tatiana Fonseca, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 10, 2008
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ
Lloyd G Czaplewski, Ian Collins, E Andrew Boyd, et al.
Journal of Medicinal Chemistry
|
October 23, 2012
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors
Michael Lainchbury, Thomas P Matthews, Tatiana McHardy, et al.
Journal of Medicinal Chemistry
|
February 16, 2010
Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt)
Tatiana McHardy, John J Caldwell, Kwai-Ming Cheung, et al.
Scientific Reports
|
October 7, 2016
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
Alan M Jones, Isaac M Westwood, James D Osborne, et al.
Science (New York, N.Y.)
|
September 20, 2008
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity
David J Haydon, Neil R Stokes, Rebecca Ure, et al.
Journal of Medicinal Chemistry
|
February 20, 2019
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease
Giampiero Colombano, John J Caldwell, Thomas P Matthews, et al.
Molecular Cancer Therapeutics
|
December 31, 2010
Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930
Timothy A Yap, Mike I Walton, Lisa-Jane K Hunter, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 30, 2013
Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ
Neil R Stokes, Nicola Baker, James M Bennett, et al.
Page
of 11
Search research articles
Search
Showing results (81-90 of 103) with videos related to
Sort By:
Page
of 11
Journal of Medicinal Chemistry
|
July 19, 2023
Determination of Ligand-Binding Affinity (<i>K</i><sub>d</sub>) Using Transverse Relaxation Rate (<i>R</i><sub>2</sub>) in the Ligand-Observed <sup>1</sup>H NMR Experiment and Applications to Fragment-Based Drug Discovery
Manjuan Liu, Amin Mirza, P Craig McAndrew, et al.
Bioorganic & Medicinal Chemistry
|
October 27, 2005
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
Ian Collins, John Caldwell, Tatiana Fonseca, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 10, 2008
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ
Lloyd G Czaplewski, Ian Collins, E Andrew Boyd, et al.
Journal of Medicinal Chemistry
|
October 23, 2012
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors
Michael Lainchbury, Thomas P Matthews, Tatiana McHardy, et al.
Journal of Medicinal Chemistry
|
February 16, 2010
Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt)
Tatiana McHardy, John J Caldwell, Kwai-Ming Cheung, et al.
Scientific Reports
|
October 7, 2016
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
Alan M Jones, Isaac M Westwood, James D Osborne, et al.
Science (New York, N.Y.)
|
September 20, 2008
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity
David J Haydon, Neil R Stokes, Rebecca Ure, et al.
Journal of Medicinal Chemistry
|
February 20, 2019
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease
Giampiero Colombano, John J Caldwell, Thomas P Matthews, et al.
Molecular Cancer Therapeutics
|
December 31, 2010
Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930
Timothy A Yap, Mike I Walton, Lisa-Jane K Hunter, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 30, 2013
Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ
Neil R Stokes, Nicola Baker, James M Bennett, et al.
Page
of 11