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Journal of Medicinal Chemistry|July 15, 2020
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo ActivityMichael G Thomas, Manu De Rycker, Richard J Wall, et al.ACS Infectious Diseases|September 15, 2021
Prioritization of Molecular Targets for Antimalarial Drug DiscoveryBarbara Forte, Sabine Ottilie, Andrew Plater, et al.Journal of Medicinal Chemistry|December 14, 2011
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitorsStephen Brand, Laura A T Cleghorn, Stuart P McElroy, et al.Journal of Medicinal Chemistry|June 21, 2023
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of AnaloguesLaura A T Cleghorn, Richard J Wall, Sébastien Albrecht, et al.European Journal of Medicinal Chemistry|May 20, 2022
Identification and development of a series of disubstituted piperazines for the treatment of Chagas diseaseKate McGonagle, Gary J Tarver, Juan Cantizani, et al.Nature|December 14, 2012
Automated design of ligands to polypharmacological profilesJérémy Besnard, Gian Filippo Ruda, Vincent Setola, et al.Journal of Medicinal Chemistry|April 27, 2021
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral LeishmaniasisMichael Thomas, Stephen Brand, Manu De Rycker, et al.Journal of Medicinal Chemistry|November 21, 2014
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasisStephen Brand, Neil R Norcross, Stephen Thompson, et al.Journal of Medicinal Chemistry|November 10, 2023
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular ActivitySimon R Green, Caroline Wilson, Thomas C Eadsforth, et al.RSC Medicinal Chemistry|January 8, 2026
Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferaseIrene Georgiou, Colin Robinson, Sean N O'Byrne, et al.Pageof 19