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ACS Medicinal Chemistry Letters
|
June 18, 2025
Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders
Jeffrey A Boerth, Marianne Schimpl, Simon C C Lucas, et al.
Journal of Medicinal Chemistry
|
December 17, 2016
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Peter Jones, R Ian Storer, Yogesh A Sabnis, et al.
ACS Medicinal Chemistry Letters
|
December 20, 2023
Rapid PROTAC Discovery Platform: Nanomole-Scale Array Synthesis and Direct Screening of Reaction Mixtures
Mateusz P Plesniak, Emilia K Taylor, Frederik Eisele, et al.
ACS Chemical Biology
|
September 13, 2022
Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains
Angelina R Sekirnik, Jessica K Reynolds, Larissa See, et al.
Journal of Medicinal Chemistry
|
March 21, 2024
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders
Simon C C Lucas, Afshan Ahmed, S Neha Ashraf, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology
|
March 17, 2015
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014
Alexander Heifetz, Gebhard F X Schertler, Roland Seifert, et al.
ACS Medicinal Chemistry Letters
|
July 17, 2024
Fragment-Based Discovery of Novel MUS81 Inhibitors
Gavin W Collie, Ulf Börjesson, Yunhua Chen, et al.
Journal of Medicinal Chemistry
|
June 1, 2014
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors
R Ian Storer, Paul E Brennan, Alan D Brown, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 15, 2017
Highly potent and selective Na<sub>V</sub>1.7 inhibitors for use as intravenous agents and chemical probes
R Ian Storer, Andy Pike, Nigel A Swain, et al.
Journal of Medicinal Chemistry
|
September 18, 2024
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, et al.
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Search research articles
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Showing results (31-40 of 45) with videos related to
Sort By:
Page
of 5
ACS Medicinal Chemistry Letters
|
June 18, 2025
Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders
Jeffrey A Boerth, Marianne Schimpl, Simon C C Lucas, et al.
Journal of Medicinal Chemistry
|
December 17, 2016
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Peter Jones, R Ian Storer, Yogesh A Sabnis, et al.
ACS Medicinal Chemistry Letters
|
December 20, 2023
Rapid PROTAC Discovery Platform: Nanomole-Scale Array Synthesis and Direct Screening of Reaction Mixtures
Mateusz P Plesniak, Emilia K Taylor, Frederik Eisele, et al.
ACS Chemical Biology
|
September 13, 2022
Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains
Angelina R Sekirnik, Jessica K Reynolds, Larissa See, et al.
Journal of Medicinal Chemistry
|
March 21, 2024
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders
Simon C C Lucas, Afshan Ahmed, S Neha Ashraf, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology
|
March 17, 2015
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014
Alexander Heifetz, Gebhard F X Schertler, Roland Seifert, et al.
ACS Medicinal Chemistry Letters
|
July 17, 2024
Fragment-Based Discovery of Novel MUS81 Inhibitors
Gavin W Collie, Ulf Börjesson, Yunhua Chen, et al.
Journal of Medicinal Chemistry
|
June 1, 2014
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors
R Ian Storer, Paul E Brennan, Alan D Brown, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 15, 2017
Highly potent and selective Na<sub>V</sub>1.7 inhibitors for use as intravenous agents and chemical probes
R Ian Storer, Andy Pike, Nigel A Swain, et al.
Journal of Medicinal Chemistry
|
September 18, 2024
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, et al.
Page
of 5