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Chemmedchem|December 7, 2018
Discovery of Affinity-Based Probes for Btk Occupancy AssaysHui Qiu, Richard Caldwell, Lesley Liu-Bujalski, et al.Bioorganic & Medicinal Chemistry Letters|September 24, 2018
Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitorsHui Qiu, Lesley Liu-Bujalski, Richard D Caldwell, et al.Cancer Discovery|January 7, 2016
Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120Shih-Hsun Chen, Youyan Zhang, Robert D Van Horn, et al.Bioorganic & Medicinal Chemistry Letters|May 8, 2007
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitorsDaniel D Holsworth, Mehran Jalaie, Thomas Belliotti, et al.Analytical Biochemistry|November 23, 2006
Binding thermodynamics of substituted diaminopyrimidine renin inhibitorsRonald W Sarver, Jeanette Peevers, Wayne L Cody, et al.Bioorganic & Medicinal Chemistry|June 19, 2007
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitorsNoel A Powell, Fred L Ciske, Cuiman Cai, et al.Bioorganic & Medicinal Chemistry|February 24, 2009
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of actionChad A Van Huis, Agustin Casimiro-Garcia, Christopher F Bigge, et al.Bioorganic & Medicinal Chemistry Letters|September 5, 2021
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitorsYufang Xiao, Bayard R Huck, Ruoxi Lan, et al.Journal of Medicinal Chemistry|October 1, 2021
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered CancersLizbeth DeSelm, Bayard Huck, Ruoxi Lan, et al.Proceedings of the National Academy of Sciences of the United States of America|January 24, 2009
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophoreJ Richard Miller, Steve Dunham, Igor Mochalkin, et al.Pageof 3