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Plos One|September 30, 2011
Characterization of the biosynthesis, processing and kinetic mechanism of action of the enzyme deficient in mucopolysaccharidosis IIICXiaolian Fan, Ilona Tkachyova, Ankit Sinha, et al.
Glycobiology|June 3, 2021
Fluorometric coupled enzyme assay for N-sulfotransferase activity of N-deacetylase/N-sulfotransferase (NDST)Joshua Atienza, Ilona Tkachyova, Michael Tropak, et al.
Scientific Reports|December 16, 2023
Evidence of an intracellular creatine-sensing mechanism that modulates creatine biosynthesis via AGAT expression in human HAP1 cellsMichael B Tropak, Ilona Tkachyova, Ray Gu, et al.
International Journal of Molecular Sciences|December 17, 2024
Validation and Optimization of a Stable Isotope-Labeled Substrate Assay for Measuring AGAT ActivityAlex Lee, Lucas Anderson, Ilona Tkachyova, et al.
Expert Opinion on Drug Discovery|October 15, 2024
Targeting AGAT gene expression - a drug screening approach for the treatment of GAMT deficiencyIlona Tkachyova, Michael B Tropak, Alex Lee, et al.
Plos One|September 23, 2016
NDST1 Preferred Promoter Confirmation and Identification of Corresponding Transcriptional Inhibitors as Substrate Reduction Agents for Multiple Mucopolysaccharidosis DisordersIlona Tkachyova, Xiaolian Fan, Anne-Marie LamHonWah, et al.
International Journal of Molecular Sciences|January 28, 2026
A CNS-Directed, AAV9 Gene Therapy Restores Expression and Biochemical Function of Guanidinoacetate Methyltransferase in Models of GAMT DeficiencyRobyn Binsfeld, Troy Webster, Ilona Tkachyova, et al.
Scientific Reports|March 2, 2025
[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutationIsabel Day, Mikayla Tamboline, Lindsay Lueptow, et al.
Plos One|March 14, 2013
In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 gangliosideIncilay Sinici, Sayuri Yonekawa, Ilona Tkachyova, et al.
Journal of Inherited Metabolic Disease|July 30, 2026
Creatine Supplementation Reduces Guanidinoacetate via Downregulation of AGAT in a Mouse Model of GAMT DeficiencyIlona Tkachyova, Dahai Wang, Alex Lee, et al.
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