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JCI Insight|July 27, 2021
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunctionKimberly A Queisser, Rebecca A Mellema, Elizabeth A Middleton, et al.Arteriosclerosis, Thrombosis, and Vascular Biology|March 5, 2026
Platelet mTOR Is a Regulator of Sterile ImmunothrombosisFrederik Denorme, Irina Portier, Heide Castro, et al.Journal of Thrombosis and Haemostasis : JTH|June 7, 2024
Aging-related alterations in mechanistic target of rapamycin signaling promote platelet hyperreactivity and thrombosisIrina Portier, Bhanu Kanth Manne, Yasuhiro Kosaka, et al.Blood|January 26, 2026
Heme-induced ITAM signaling exacerbates malaria-associated neuropathogenesis through activation of platelet mTORIrina Portier, Frederik Denorme, Neal D Tolley, et al.Circulation Research|July 1, 2025
Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet ActivationAbigail Ajanel, Izabella Andrianova, Mia Kowalczyk, et al.The Journal of Clinical Investigation|March 31, 2022
Neutrophil extracellular traps regulate ischemic stroke brain injuryFrederik Denorme, Irina Portier, John L Rustad, et al.Blood|June 24, 2020
Platelet gene expression and function in patients with COVID-19Bhanu Kanth Manne, Frederik Denorme, Elizabeth A Middleton, et al.Blood|August 5, 2022
MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosisBhanu Kanth Manne, Robert A Campbell, Seema Bhatlekar, et al.The Journal of Clinical Investigation|July 20, 2023
The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomesFrederik Denorme, Nicole D Armstrong, Michelle L Stoller, et al.Blood|June 30, 2020
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndromeElizabeth A Middleton, Xue-Yan He, Frederik Denorme, et al.Pageof 2