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ACS Chemical Neuroscience|August 29, 2024
Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase InhibitorsRim Malek, Kinga Sałat, Perle Totoson, et al.
ACS Omega|January 1, 2020
Chromenones as Multineurotargeting Inhibitors of Human EnzymesCarina Lemke, Joscha Christmann, Jiafei Yin, et al.
Cell Death & Disease|April 4, 2025
Generation and validation of a novel multitarget small molecule in glioblastomaAizpea Artetxe-Zurutuza, Nerea Iturrioz-Rodriguez, Joseba Elizazu, et al.
European Journal of Medicinal Chemistry|February 17, 2019
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenaseEhab D AlFadly, Perihan A Elzahhar, Anna Tramarin, et al.
Journal of Medicinal Chemistry|November 15, 2019
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase InhibitionRim Malek, Raquel L Arribas, Alejandra Palomino-Antolin, et al.
Angewandte Chemie (International Ed. in English)|September 2, 2017
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative DiseasesÓscar M Bautista-Aguilera, Stefanie Hagenow, Alejandra Palomino-Antolin, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|September 28, 2025
N-Methyl-N-((1-methyl-5-(3-(piperidin-1-yl)propoxy)-1H-benzo[d]imidazol-2-yl)methyl)prop-2-yn-1-amine (MBA-159), a new multitarget small molecule for the therapy of Alzheimer's diseaseÓscar M Bautista-Aguilera, Aleksandra Manik, Daniel Diez-Iriepa, et al.
International Journal of Molecular Sciences|April 14, 2026
Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-Based Therapy of Parkinson's DiseaseMireia Toledano-Pinedo, Alicia Porro-Pérez, Linda Schäker-Hübner, et al.
Journal of Medicinal Chemistry|September 10, 2024
Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative DiseasesMireia Toledano-Pinedo, Alicia Porro-Pérez, Linda Schäker-Hübner, et al.
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