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Journal of Biochemistry|December 27, 2024
Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibitionHiroki Shimura, Sota Yamamoto, Isshin Shiiba, et al.Biomolecules|March 19, 2020
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease PatientsTakeshi Tokuyama, Asei Hirai, Isshin Shiiba, et al.Journal of Biochemistry|April 18, 2020
MITOL dysfunction causes dwarfism with anterior pituitary hypoplasiaKeigo Matsuno, Shun Nagashima, Isshin Shiiba, et al.EMBO Reports|February 10, 2021
MITOL promotes cell survival by degrading Parkin during mitophagyIsshin Shiiba, Keisuke Takeda, Shun Nagashima, et al.Scientific Reports|December 29, 2019
Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodiesShun Nagashima, Keisuke Takeda, Isshin Shiiba, et al.The EMBO Journal|August 2, 2019
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sitesKeisuke Takeda, Shun Nagashima, Isshin Shiiba, et al.Nature Communications|March 6, 2026
STIM1-Mitofusin2 interactions tether mitochondria and melanosome contacts that promote melanosome maturationIsshin Shiiba, Yuto Ishikawa, Hijiri Oshio, et al.Nature Cell Biology|June 10, 2026
Mitochondria-ER contacts function as an iron supply hubHijiri Oshio, Isshin Shiiba, Naoki Ito, et al.Iscience|July 5, 2022
Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulationTakeshi Tokuyama, Hideki Uosaki, Ayumu Sugiura, et al.Npj Aging|March 21, 2026
Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunctionMichio Sato, Daishi Tanabu, Daisuke Torigoe, et al.Pageof 3