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Nature
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February 5, 2010
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou, Kyung Song, Ivana Yen, et al.
ACS Medicinal Chemistry Letters
|
May 31, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor
Malcolm P Huestis, Matthew R Durk, Charles Eigenbrot, et al.
ACS Medicinal Chemistry Letters
|
January 29, 2016
Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR
Marian C Bryan, Daniel J Burdick, Bryan K Chan, et al.
Cell Reports
|
February 9, 2022
CRAF dimerization with ARAF regulates KRAS-driven tumor growth
Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 1, 2013
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
Peter S Dragovich, Benjamin P Fauber, Laura B Corson, et al.
Journal of Medicinal Chemistry
|
March 29, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
Malcolm P Huestis, Darlene Dela Cruz, Antonio G DiPasquale, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 4, 2014
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase
Sharada Labadie, Peter S Dragovich, Jinhua Chen, et al.
Journal of Medicinal Chemistry
|
November 11, 2014
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation
Emily J Hanan, Charles Eigenbrot, Marian C Bryan, et al.
Journal of Medicinal Chemistry
|
March 12, 2016
Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Robert Heald, Krista K Bowman, Marian C Bryan, et al.
Journal of Medicinal Chemistry
|
October 13, 2015
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Robert Heald, Krista K Bowman, Marian C Bryan, et al.
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Showing results (11-20 of 28) with videos related to
Sort By:
Page
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Nature
|
February 5, 2010
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou, Kyung Song, Ivana Yen, et al.
ACS Medicinal Chemistry Letters
|
May 31, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor
Malcolm P Huestis, Matthew R Durk, Charles Eigenbrot, et al.
ACS Medicinal Chemistry Letters
|
January 29, 2016
Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR
Marian C Bryan, Daniel J Burdick, Bryan K Chan, et al.
Cell Reports
|
February 9, 2022
CRAF dimerization with ARAF regulates KRAS-driven tumor growth
Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 1, 2013
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
Peter S Dragovich, Benjamin P Fauber, Laura B Corson, et al.
Journal of Medicinal Chemistry
|
March 29, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
Malcolm P Huestis, Darlene Dela Cruz, Antonio G DiPasquale, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 4, 2014
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase
Sharada Labadie, Peter S Dragovich, Jinhua Chen, et al.
Journal of Medicinal Chemistry
|
November 11, 2014
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation
Emily J Hanan, Charles Eigenbrot, Marian C Bryan, et al.
Journal of Medicinal Chemistry
|
March 12, 2016
Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Robert Heald, Krista K Bowman, Marian C Bryan, et al.
Journal of Medicinal Chemistry
|
October 13, 2015
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Robert Heald, Krista K Bowman, Marian C Bryan, et al.
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